![]() ![]() Prolonged bedrest leads to increased heart rate and changes in body vascular resistance 2 and increases the risk of hospital-acquired pneumonia, an important cause of morbidity and mortality in hospitalized patients, which is often caused by bacterial infection 3, 4. In healthy older adults, as little as 10 days of bedrest is associated with considerable loss of strength and aerobic capacity, as well as with a tendency towards reduced physical activity that can last weeks 1. Physical inactivity or bedrest during hospitalization has been proposed as a primary factor contributing to the functional decline of hospitalized patients 1. Resistive vibration exercise during bedrest did not correct HDL levels and impaired cholesterol efflux capacity. In conclusion, prolonged bedrest reduces plasma HDL levels linked to markedly suppressed HDL cholesterol efflux capacity. Resistive vibration exercise countermeasure during bedrest did not correct impaired cholesterol efflux capacity and only tended to increase arylesterase activity of HDL-associated paraoxonase. No change was observed in the content of HDL-associated serum amyloid A, a sensitive marker of inflammation. Paraoxonase activity, plasma anti-oxidative capacity and the activities of lecithin-cholesterol acyltransferase and cholesteryl ester transfer protein were not affected. We observed that HDL cholesterol efflux capacity was profoundly decreased during bedrest, mediated by a bedrest associated reduction in plasma levels of HDL-cholesterol and major apolipoproteins (apo) apoA-I and apoA-II. We evaluated metrics of HDL composition and function in healthy male volunteers participating in a randomized, crossover head-down bedrest study. Effects of prolonged bedrest on the composition and functional properties of HDL remain elusive. ![]() The immobility associated with prolonged bedrest is detrimental to health, affecting several systems, including the cardiovascular, pulmonary, gastrointestinal, musculoskeletal and urinary. To date, our knowledge of factors determining this connection is still very limited. Recent observations strongly connect high-density lipoproteins (HDL) function and levels with coronary heart disease outcomes and risk for infections and sepsis. ![]()
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